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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.
First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.
Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
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A distant relative of Qatar’s ruling family, founder and chairman of Al Faisal Holdings (one of Qatar’s biggest conglomerates), and a billionaire whose business acumen had him recognized as one of the most influential Arab businessmen in the world, Sheikh Faisal had already amassed a substantial private collection of historically important regional artifacts, plus a few quirky pieces of interest, allowing visitors an intimate look into Qatari life and history.
In an interview with Qatari channel Alrayyan TV in 2018, Sheikh Faisal said that the museum started as a hobby.
“I used to collect items whenever I got the chance,” he said. “As my business grew, so did my collections, and soon I was able to collect more and more items until I decided to put them in the museum for the public to enjoy.”
His private cabinet of curiosities has since evolved into a 130-acre complex. Through the fort-like entrance gate lies an oryx reserve, an impressive riding school and stables, a duck pond and a mosque built with a quirky leaning minaret. There’s now even a five-star Marriott hotel, two cafes and the Zoufa restaurant serving modern Lebanese cuisine.
Of course, there’s also the super-sized museum, with a recently-opened car collection housing everything from vintage Rolls-Royces to wartime Jeeps and colorful Buicks. Outside you’ll find peacocks roaming the grounds, and signs warning drivers to be aware of horses and ostriches.
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Some scientists believe that fatty acids such as decanoic acid and dodecanoic acid formed the membranes of the first simple cell-like structures on Earth, Pearce said. connext bridge
“(This is) the closest we’ve come to detecting a major biomolecule-related signal — something potentially tied to membrane structure, which is a key feature of life,” Pearce said via email. “Organics on their own are intriguing, but not evidence of life. In contrast, biomolecules like membranes, amino acids, nucleotides, and sugars are central components of biology as we know it, and finding any of them would be groundbreaking (we haven’t yet).”
Returning samples from Mars
The European Space Agency plans to launch its ExoMars Rosalind Franklin rover to the red planet in 2028, and the robotic explorer will carry a complementary instrument to SAM. The rover LS6 will have the capability to drill up to 6.5 feet (2 meters) beneath the Martian surface — and perhaps find larger and better-preserved organic molecules.
While Curiosity’s samples can’t be studied on Earth, the Perseverance rover has actively been collecting samples from Jezero Crater, the site of an ancient lake and river delta, all with the intention of returning them to Earth in the 2030s via a complicated symphony of missions called Mars Sample Return.
Both rovers have detected a variety of organic carbon molecules in different regions on Mars, suggesting that organic carbon is common on the red planet, Williams said.
While Curiosity and Perseverance have proven they can detect organic matter, their instruments can’t definitively determine all the answers about their origins, said Dr. Ashley Murphy, postdoctoral research scientist at the Planetary Science Institute. Murphy, who along with Williams previously studied organics identified by Perseverance, was not involved in the new research.
“To appropriately probe the biosignature question, these samples require high-resolution and high-sensitivity analyses in terrestrial labs, which can be facilitated by the return of these samples to Earth,” Murphy said.
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Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.
Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.
The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.
First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.
Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.
“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”
Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.
Within a day or two of birth, the authors collected the babies’ blood via a heel stick.
The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.
Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.
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A distant relative of Qatar’s ruling family, founder and chairman of Al Faisal Holdings (one of Qatar’s biggest conglomerates), and a billionaire whose business acumen had him recognized as one of the most influential Arab businessmen in the world, Sheikh Faisal had already amassed a substantial private collection of historically important regional artifacts, plus a few quirky pieces of interest, allowing visitors an intimate look into Qatari life and history.
In an interview with Qatari channel Alrayyan TV in 2018, Sheikh Faisal said that the museum started as a hobby.
“I used to collect items whenever I got the chance,” he said. “As my business grew, so did my collections, and soon I was able to collect more and more items until I decided to put them in the museum for the public to enjoy.”
His private cabinet of curiosities has since evolved into a 130-acre complex. Through the fort-like entrance gate lies an oryx reserve, an impressive riding school and stables, a duck pond and a mosque built with a quirky leaning minaret. There’s now even a five-star Marriott hotel, two cafes and the Zoufa restaurant serving modern Lebanese cuisine.
Of course, there’s also the super-sized museum, with a recently-opened car collection housing everything from vintage Rolls-Royces to wartime Jeeps and colorful Buicks. Outside you’ll find peacocks roaming the grounds, and signs warning drivers to be aware of horses and ostriches.
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Some scientists believe that fatty acids such as decanoic acid and dodecanoic acid formed the membranes of the first simple cell-like structures on Earth, Pearce said.
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“(This is) the closest we’ve come to detecting a major biomolecule-related signal — something potentially tied to membrane structure, which is a key feature of life,” Pearce said via email. “Organics on their own are intriguing, but not evidence of life. In contrast, biomolecules like membranes, amino acids, nucleotides, and sugars are central components of biology as we know it, and finding any of them would be groundbreaking (we haven’t yet).”
Returning samples from Mars
The European Space Agency plans to launch its ExoMars Rosalind Franklin rover to the red planet in 2028, and the robotic explorer will carry a complementary instrument to SAM. The rover LS6 will have the capability to drill up to 6.5 feet (2 meters) beneath the Martian surface — and perhaps find larger and better-preserved organic molecules.
While Curiosity’s samples can’t be studied on Earth, the Perseverance rover has actively been collecting samples from Jezero Crater, the site of an ancient lake and river delta, all with the intention of returning them to Earth in the 2030s via a complicated symphony of missions called Mars Sample Return.
Both rovers have detected a variety of organic carbon molecules in different regions on Mars, suggesting that organic carbon is common on the red planet, Williams said.
While Curiosity and Perseverance have proven they can detect organic matter, their instruments can’t definitively determine all the answers about their origins, said Dr. Ashley Murphy, postdoctoral research scientist at the Planetary Science Institute. Murphy, who along with Williams previously studied organics identified by Perseverance, was not involved in the new research.
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